Given that Tysabri remains very popular for many making the same calculations my wife and I have on the value of continuing usage despite the risks, it would seem dealing with any signs of depression should be deemed very important. Granted, in the past 20 years treatments have come a long way, but everything I read suggests depression is still quite common. In family notes, we have been battling to get K out of hospital and keep her out as she battles a stomache virus for the past 5 days. Sometimes one has to smile even in the face of gross:. I have been on tysabri for 74 infusions thus far. Before it, I was flaring constantly with losses like the ability to swallow and sense of balance to the point where the only exercises I could do were climbing stairs with railings and the rowing machine where if I fell it was 4 inches.