By Andrew Collins. Gay nightlife is alive and well in the Tampa , Florida area. Here's our take on the best bars and nightclubs plus a gay-popular restaurant in Tampa and its bustling nightlife district, Ybor City. The third largest population , city in the state and the largest city on Florida's Gulf Coast, Tampa has a sizable gay scene and plenty of GLBT nightspots. An added bonus—it's just a quick drive to the many gay bars and gay-friendly restaurants of St. Petersburg and the other beach cities along the Gulf Coast.